Turn to God for help first. I also suggest you read what Job, the man mentioned in the Bible who went through intense pain and suffered the loss of all of his family. Even his friends turned against him and made long speeches against him. Despite that, he was rescued by God and is now known all over the world for his victory over Satan’s attempt to completely turn him against God.

And here is my story:

Without God’s love, you will always crave more and more and never be content.

Without a friend that gives you an honest answer when you want one, who gives you one out of love, you will always feel some misery. And if you only have friends that flatter you, you may be depressed knowing that they are doing so because they want to take advantage of you in some way rather than truly loving you, or loving you with a pure love, love which isn’t self-seeking.

Also, you may have a poor diet which is causing a chemical imbalance or making you depressed due to its blandness, have past trauma that is still bothering you because you don’t know how to deal with it or because it was very painful, are encountering unpleasant smells often (like perhaps from a new rug which smells bad), have bland surroundings (you may want to decorate your walls with posters), have unpleasant parents, don’t have friends or ones that give you bad to no advice when you ask for the help or when it’s obvious you need it, you may have a boring getting-no-where life, or you may feel as if you’re not getting your way in general (which frustrates everyone who feels that way).

I had problems with depression and suicide due to my parents neglecting my education, including knowledge about right from wrong, and not having much interesting or helpful to do. I also got bullied at school for how I was dressed and appeared before I was 14 and of course, instead of the bullies being punished I was the one who got stuck in a miserable substitute for a "normal" public high school and had next to no friends while there (and still have about none). Soon after attending that school I was bullied by the police off an on a few times. Other miserable things happened including being repeatedly kicked out and being mistreated at nearly all the jobs I had by coworkers or bosses who harassed me out of them. But, God saved me and helped me beat my depression and allowed and helped me to accomplish some great things that I can take comfort in having accomplished no matter how miserable. I’m still depressed sometimes, but it’s not as bad now since he’s opened my eyes.

Check out the link in my profile if you are interested in spiritual help, which I found has been a lasting and permanent solution heading towards perfect peace. I hope you show the link to others.
References :
History and experience (including the experience of 100+ million Christians).